Chalcones as versatile synthons for the synthesis of 5 and 6. The chemistry of chalcones and related compounds book, 1981. Various mannich bases of chalcones and related compounds displayed significant cytotoxicity toward murine p388 and l1210 leukemia cells as well as a number of human tumor cell lines. Chalcones are also known as benzyl acetophenone or benzylidene acetophenone. They possess different activities like antibacterial, antifungal, antiinflammatory and anti tumor etc depending on the sub stitution made on them. The chemistry of chalcones and related compounds book. The chemistry of chalcone has been recognized as a significant field of study.
Synthesis, characterization and pharmacological activity. The name chalcones was given by kostanecki and tambor 1. Buy the chemistry of chalcones and related compounds on. The synthesized compounds were characterized by means of their ir and. Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. The chemistry of chalcones has generated intensive scientific studies throughout the world.
Synthesis, characterization and computational study of some new. They possess different activities like antibacterial, antifungal, antiinflammatory and anti tumor etc depending on the sub. Chemical and biological potentials of chalcones juniper publishers. Chalcone and related compounds chalconoids is an ar. Chalcones are also intermediates in the auwers synthesis of flavones. Synthesis and medicinal significance of chalcones allied academies. The chemistry of chalcones and related compounds durga nath dhar. In chalcones, two aromatic rings are linked by an aliphatic three carbon chain. In addition, 21 exerted preferential toxicity to human tumor lines compared to transformed human t. The most promising lead molecule was 21 that had the highest activity toward l1210 and human tumor cells.
Chalcones, aromatic ketones and enones, are known for their anticancer effects. The chemistry of chalcones and related compounds durga nath. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Although parent chalcones consist of two aromatic rings joined by a threecarbon. An aromatic ketone that forms the core molecule of chalcones.
Dhar, the chemistry of chalcones and related compounds. Pdf chemistry of chalcone synthesis and its derivatives. The chemistry of chalcones remains a fascination among researchers in the. Pdf on may 19, 2015, rajarshi patel and others published chemistry of chalcone synthesis and its derivatives find, read and cite all the research you need on researchgate. One of the compounds, nutlin2, 60, was cocrystallized with mdm2 and the structure solved by xray diffraction. It is a member of styrenes and a member of chalcones. Chemical and structural properties of chalcones i fabad journal. Chalcone is an aromatic ketone that forms a central core for a variety of important biologi cal compounds, which are collectively known as chalcones.
The complex obtained showed that the compound bound with the imidazole ring as a scaffold projecting three hydrophobic groups into the three hydrophobic pockets in an analogous manner to p53. Reaction of chalcones with the compounds having active methylene group. Silva studied chemistry at the university of aveiro. Cytotoxic activities of mannich bases of chalcones and.
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